Pkd1 and Pkd2 Are Required for Normal Placental Development
نویسندگان
چکیده
منابع مشابه
Pkd1 and Pkd2 Are Required for Normal Placental Development
BACKGROUND Autosomal dominant polycystic kidney disease (ADPKD) is a common cause of inherited renal failure that results from mutations in PKD1 and PKD2. The disorder is characterized by focal cyst formation that involves somatic mutation of the wild type allele in a large fraction of cysts. Consistent with a two-hit mechanism, mice that are homozygous for inactivating mutations of either Pkd1...
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The authors would like to thank Sonja Scheffer for help with DNA sequencing and Roberta Henegar, Sharon Ochs, Nicole Guimond, and Patrice Armstrong for excellent technical assistance. Mention of a trade name or commercial product in this publication is solely for the purpose of providing specific information and does not imply recommendation or endorsement by the U.S. Department of Agriculture....
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2010
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0012821